Kidney Int 2004;66(6):2422-2428. Int J Sports Med. Clin Ter. View abstract. Lancet 9-21-1996;348(9030):789-790. Yáñez-Silva A, Buzzachera CF, Piçarro IDC, Januario RSB, Ferreira LHB, McAnulty SR, Utter AC, Souza-Junior TP. Volek, J. S., Mazzetti, S. A., Farquhar, W. B., Barnes, B. R., GOMEZ And AL, and Kraemer, W. J. Physiological responses to short-term exercise in the heat after creatine loading. -, Med Sci Sports Exerc. View abstract. Lanhers C, Pereira B, Naughton G, et al. View abstract. View abstract. NIH 2001;1. View abstract. The consumption of oral creatine monohydrate has become increasingly common among professional and amateur athletes. View abstract. Kreider RB, Kalman DS, Antonio J, et al. View abstract. View abstract. Bodamer, O. Proc Natl Acad Sci U S A 1993;90:3304-8. Nutrition 2011;27(4):451-455. Med Sci Sports Exerc 1999;31:1763-9. Sports Med 2015;45(9):1285-94. CREATINE SUPPLEMENTATION AND SPRINT TRAINING IN CYCLISTS: METABOLIC AND PERFORMANCE EFFECTS. View abstract. NINDS NET-PD Investigators. Early research on the effects of creatine in people with chronic obstructive pulmonary disease (COPD) is inconsistent. 1997;53(4):343-348. View abstract. It’s very common to appear The effects of ergogenic compounds on myogenic satellite cells. J Appl.Physiol 2003;95(2):818-828. View abstract. Available at: https://www.usada.org/substances/prohibited-list/. J Appl Physiol 1996;80:452-7. The following doses have been studied in scientific research: The American College of Sports Medicine Roundtable on the physiological and health effects of oral creatine supplementation. Med.Sci.Sports Exerc. Aust J Sci Med Sport 1995;27:56-61. Holtzman, D., Togliatti, A., Khait, I., and Jensen, F. Creatine increases survival and suppresses seizures in the hypoxic immature rat. Vasc.Med. View abstract. View abstract. A., Hartman, M. J., Stout, J. R., and Cramer, J. T. Effects of creatine monohydrate and polyethylene glycosylated creatine supplementation on muscular strength, endurance, and power output. Journal of Child Neurology 2007;22(8):1027-1049. Int J Sport Nutr.Exerc.Metab 2000;10(3):277-289. 2010;24(11):988-999. View abstract. View abstract. Green AL, Hultman E, Macdonald IA, et al. View abstract. View abstract. 2012;4:CD004426. 2010;28(3):388-6. Cochrane.Database.Syst.Rev. J Strength.Cond.Res 2001;15(4):413-419. Renema, W. K., Schmidt, A., van Asten, J. J., Oerlemans, F., Ullrich, K., Wieringa, B., Isbrandt, D., and Heerschap, A. MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)-deficient mice: validation of an animal model to study creatine deficiency. View abstract. Drory, V. E. and Gross, D. No effect of creatine on respiratory distress in amyotrophic lateral sclerosis. J Sports Sci. Dyskinesia in Parkinson's: What Causes It? View abstract. View abstract. Smith, S. A., Montain, S. J., Matott, R. P., Zientara, G. P., Jolesz, F. A., and Fielding, R. A. Creatine supplementation and age influence muscle metabolism during exercise. Jäger R, Purpura M, Shao A, Inoue T, Kreider RB. View abstract. View abstract. J Cardiovasc Surg (Torino) 1996;37:75-80. Amyotroph.Lateral.Scler. Teicher, B. Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. View abstract. Bender A, Koch W, Elstner M, et al. Brose, A., Parise, G., and Tarnopolsky, M. A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. Creapure (Creatine Monohydrate). Early research in people with inherited nerve damage diseases such as Charcot-Marie-Tooth Disease shows that taking creatine by mouth daily for between one and 12 weeks has no effect on muscle strength or endurance. Int J Sport Nutr.Exerc.Metab 2003;13(2):173-183. Pluim, B. M., Ferrauti, A., Broekhof, F., Deutekom, M., Gotzmann, A., Kuipers, H., and Weber, K. The effects of creatine supplementation on selected factors of tennis specific training. Deminice R, Rosa FT, Pfrimer K, Ferrioli E, Jorao AA, Freitas E. Creatine supplementation increases total body water in soccer players: a deuterium oxide dilution study. View abstract. Acute creatine supplementation in older men. View abstract. Syrotuik, D. G. and Bell, G. J. This content is imported from {embed-name}. Almeida, L. S., Rosenberg, E. H., Martinez-Munoz, C., Verhoeven, N. M., Vilarinho, L., Jakobs, C., and Salomons, G. S. Overexpression of GAMT restores GAMT activity in primary GAMT-deficient fibroblasts. Effect of oral creatine supplementation on muscle [PCr] and short-term maximum power output. In Vivo 1998;12(2):223-231. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine. Effect of creatine ingestion on glucose tolerance and insulin sensitivity in men. Aust.J Sci.Med Sport 1997;29(3):65-68. Laser Reutersward A, Skog K, Jagerstad M. Mutagenicity of pan-fried bovine tissues in relation to their content of creatine, creatinine, monosaccharides and free amino acids. Int J Sports Med 2001;22(8):546-552. Boca Raton, FL: CRC Press, LLC 1994. (abstract) Res Q Exerc Sport 1997;68:233-40. View abstract. An inherited disorder marked by vision loss (gyrate atrophy). Int J Sports Med 2001;22(1):76-80. Gastrointestinal disturbances and muscle cramps have been reported occasionally in healthy individuals, but the effects are anecdotal. O'Rourke, D. J., Ryan, S., Salomons, G., Jakobs, C., Monavari, A., and King, M. D. Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. View abstract. A., Menon, K., Northey, D., Liu, J., Kufe, D. W., and Kaddurah-Daouk, R. Cyclocreatine in cancer chemotherapy. 1993;39(2):153-159. Pharmacotherapy 2005;25:762-4. Grindstaff, P. D., Kreider, R., Bishop, R., Wilson, M., Wood, L., Alexander, C., and Almada, A. J Strength.Cond.Res 2003;17(3):439-445. But the effect of creatine on sprinting, cycling, or swimming performance varies. 8-1-2008;178(3):233-239. View abstract. View abstract. Ling, J., Kritikos, M., and Tiplady, B. Cognitive effects of creatine ethyl ester supplementation. Neuroprotective effects of creatine and cyclocreatine in animal models of Huntington's disease. View abstract. View abstract. eCollection 2017. Med Sci.Sports Exerc. Escolar, D. M., Buyse, G., Henricson, E., Leshner, R., Florence, J., Mayhew, J., Tesi-Rocha, C., Gorni, K., Pasquali, L., Patel, K. M., McCarter, R., Huang, J., Mayhew, T., Bertorini, T., Carlo, J., Connolly, A. M., Clemens, P. R., Goemans, N., Iannaccone, S. T., Igarashi, M., Nevo, Y., Pestronk, A., Subramony, S. H., Vedanarayanan, V. V., and Wessel, H. CINRG randomized controlled trial of creatine and glutamine in Duchenne muscular dystrophy. Med Sci.Sports Exerc. View abstract. Ziegenfuss T, Lowery LM, and Lemon PW. View abstract. Discusses the effects of creatine monohydrate, side effects, dangers and the actual benefits of creatine. View abstract. A. Absorption of creatine supplied as a drink, in meat or in solid form. J Neurosci 1998;18:156-63. View abstract. Endocrine 2014;45(3):354-61. de Guingand DL, Palmer KR, Snow RJ, Davies-Tuck ML, Ellery SJ. Jacobs, I., Bleue, S., and Goodman, J. Creatine ingestion increases anaerobic capacity and maximum accumulated oxygen deficit. View abstract. Carcinogenesis 1992;13:827-830. J.Strength.Cond.Res. Hibbard MK, Sandri-Goldin, RM. Cochrane.Database.Syst.Rev. View abstract. View abstract. Clin.Neuropharmacol. Br.J Sports Med 2000;34(4):284-288. 2002;34(2):332-343. 2009;41(10):1934-1941. J Nutr Health Aging 2005;9(5):352-353. View abstract. View abstract. Grazioli I, Melzi G, and Strumia E. Multicenter controlled study of creatine phosphate in the treatment of heart failure. 2019;44(11):1246-1253. 2011;25(7):1831-1838. View abstract. Creatine supplementation does not alter neuromuscular recovery after eccentric exercise. Kirksey KB, Warren BJ, Stone MH, and et al. Available at: https://www.nytimes.com/1997/12/19/sports/wrestling-collegiate-wrestling-deaths-raise-fears-about-training.html. Lou Gehrig disease (amyotrophic lateral sclerosis or ALS). A pilot study. J Thorac.Cardiovasc.Surg. Would you like email updates of new search results? Resistance training and co-supplementation with creatine and protein in older subjects with frailty. Diabetes. Early research shows that taking creatine by mouth daily in combination with strengthening exercises improves physical functioning in postmenopausal women with knee osteoarthritis. Fatal rhabdomyolysis with bilateral gluteal, thigh, and leg compartment syndrome after the Army Physical Fitness Test. 2004;23(5):524. Arch Dermatol 2006;142:1662-3. 2017 Aug 8;89(6):594-601. May 2, 1998. A., Bloesch, S. M., Gregg, A. R., Stockler-Ipsiroglu, S., and O'Brien, W. E. Analysis of guanidinoacetate and creatine by isotope dilution electrospray tandem mass spectrometry. McNaughton LR, Dalton B, Tarr J. Medicine & Science in Sports & Exercise 1996;28(5):81. (abstract) J Appl Physiol 1998;84:1667-73. Ensenauer, R., Thiel, T., Schwab, K. O., Tacke, U., Stockler-Ipsiroglu, S., Schulze, A., Hennig, J., and Lehnert, W. Guanidinoacetate methyltransferase deficiency: differences of creatine uptake in human brain and muscle. View abstract. Effects of oral creatine supplementation on multiple sprint cycle performance. Andreev NA, Andreeva TN, and Bichkov IV. View abstract. View abstract. J.Strength.Cond.Res. J Ethnopharmacol 1991;31:283-9. Knott, A., Koop, U., Mielke, H., Reuschlein, K., Peters, N., Muhr, G. M., Lenz, H., Wensorra, U., Jaspers, S., Kolbe, L., Raschke, T., Stab, F., Wenck, H., and Gallinat, S. A novel treatment option for photoaged skin. (abstract) Med Sci Sports Exerc 1998;30:73-82. View abstract. View abstract. Sakellaris, G., Nasis, G., Kotsiou, M., Tamiolaki, M., Charissis, G., and Evangeliou, A. Tan CW, Hae Tha M, Joo Ng H. Creatine supplementation and venous thrombotic events. View abstract. J.Strength.Cond.Res. Metabolism 2001;50(12):1429-1434. Benatar, M., Kurent, J., and Moore, D. H. Treatment for familial amyotrophic lateral sclerosis/motor neuron disease. J.Strength.Cond.Res. Amino.Acids 2008;35(2):425-431. Cochrane.Database.Syst.Rev. Gualano, B., Ferreira, D. C., Sapienza, M. T., Seguro, A. C., and Lancha, A. H., Jr. Effect of short-term high-dose creatine supplementation on measured GFR in a young man with a single kidney. View abstract. 1997;7(4):330-346. The influence of oral creatine supplementation on muscle phosphocreatine resynthesis following intense contraction in man. View abstract. View abstract. Stevenson, S. W. and Dudley, G. A. Creatine loading, resistance exercise performance, and muscle mechanics. View abstract. View abstract. View abstract. View abstract. Mol.Genet.Metab 2002;77(4):326-331. Effects of creatine supplementation on aerobic power and cardiovascular structure and function. View abstract. Tarnopolsky, M. A., Mahoney, D. J., Vajsar, J., Rodriguez, C., Doherty, T. J., Roy, B. D., and Biggar, D. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Med Sci.Sports Exerc. In children with this condition, taking creatine for up to 8 years seems to improve attention, language, and mental performance. View abstract. Mazzini, L., Balzarini, C., Colombo, R., Mora, G., Pastore, I., De Ambrogio, R., and Caligari, M. Effects of creatine supplementation on exercise performance and muscular strength in amyotrophic lateral sclerosis: preliminary results. View abstract. J.Cosmet.Dermatol. 9-3-2008;95(1-2):130-134. J Clin Pharmacol 2003;43:29-37. . Cafiero, M., Strumia, E., Pirone, S., Pacileo, S., and Santoro, R. [The efficacy of creatine phosphate in the treatment of patients with heart failure. Bender, A., Samtleben, W., Elstner, M., and Klopstock, T. Long-term creatine supplementation is safe in aged patients with Parkinson disease. Verbessem, P., Lemiere, J., Eijnde, B. O., Swinnen, S., Vanhees, L., Van Leemputte, M., Hespel, P., and Dom, R. Creatine supplementation in Huntington's disease: a placebo-controlled pilot trial. Ahmun, R. P., Tong, R. J., and Grimshaw, P. N. The effects of acute creatine supplementation on multiple sprint cycling and running performance in rugby players. Br J Sports Med 2006;40(6):507-511. J Strength.Cond.Res 2005;19(2):260-264. But like any supplement, there is a chance that it can cause unwanted side effects. Side Effects of Creatine The creatine substance has been tested and examined in large numbers of studies for almost 50 years, contributing to the claims that it’s a safe and well-tested substance. Med Sci Sports Exerc 2000;32:291-6. Cochrane.Database.Syst.Rev. Oxid.Med.Cell Longev. Med Sci.Sports Exerc. J.Strength.Cond.Res. Diarrhea 4. View abstract. Birch R, Noble D, Greenhaff PL. The reason for this is that intake of creatine draws water into the muscles and that reflects as an increase in weight. Heinanen K, Nanto-Salonen K, Komu M, et al. Int J Sports Med 2000;21:71-5. Ayoama, R., Hiruma, E., and Sasaki, H. Effects of creatine loading on muscular strength and endurance of female softball players. Consensus statement for standard of care in spinal muscular atrophy. Mercimek-Mahmutoglu, S., Connolly, M. B., Poskitt, K. J., Horvath, G. A., Lowry, N., Salomons, G. S., Casey, B., Sinclair, G., Davis, C., Jakobs, C., and Stockler-Ipsiroglu, S. Treatment of intractable epilepsy in a female with SLC6A8 deficiency. Bergnes G, Yuan W, Khandekar VS, et al. Muscle Nerve 2004;29(1):51-58. But creatine doesn't seem to improve wrist muscle or hand function. View abstract. View abstract. View abstract. View abstract. WADA Prohibited List. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. The effects of creatine supplementation on muscular performance and body composition responses to short-term resistance training overreaching. View abstract. Banerjee, B., Sharma, U., Balasubramanian, K., Kalaivani, M., Kalra, V., and Jagannathan, N. R. Effect of creatine monohydrate in improving cellular energetics and muscle strength in ambulatory Duchenne muscular dystrophy patients: a randomized, placebo-controlled 31P MRS study. View abstract. Diabetes 2001;50(1):18-23. Acute fluid volume changes in men during three days of creatine supplementation. Med Sci Sports Exerc 2004;36(10):1781-1788. J.Strength.Cond.Res. Nevertheless, idiosyncratic effects may occur when large amounts of an exogenous substance containing an amino group are consumed, with the consequent increased load on the liver and kidneys. Can J Appl.Physiol 2001;26(6):527-542. Baker TP, Candow DG, Farthing JP. View abstract. J Appl.Physiol 2003;94(5):1910-1916. Hersch SM, Schifitto G, Oakes D, et al. View abstract. 1975;105(4):428-438. Huyzen RJ, Harder MP, Huet RC, et al. Neurology 5-25-2004;62(10):1771-1777. Scand.J Med Sci.Sports 1998;8(5 Pt 1):247-251. Int J Sport Nutr. The most common adverse effect is transient water retention in the early stages of supplementation. Low bone mass (osteopenia). View abstract. Smith, J. C., Stephens, D. P., Hall, E. L., Jackson, A. W., and Earnest, C. P. Effect of oral creatine ingestion on parameters of the work rate-time relationship and time to exhaustion in high-intensity cycling. Manabe S, Kurihara N, Wada O, et al. Early research shows that taking creatine by mouth daily increases lean muscle mass and may improve muscle strength, but does not improve physical functioning in adults with rheumatoid arthritis. 2011;10(4):273-281. Saremi A, Gharakhanloo R Sharghi S Gharaati MR Larijani B Omidfar K. Effects of oral creatine and resistance training on serum myostatin and GASP-1. Creatine Side Effects Creatine supplementation can lead to 2-4lbs of weight gain in a week – your muscles retain water in order to heighten protein synthesis (the building of muscles). Clin Chim.Acta 2005;361(1-2):1-9. Rosenfeld, J., King, R. M., Jackson, C. E., Bedlack, R. S., Barohn, R. J., Dick, A., Phillips, L. H., Chapin, J., Gelinas, D. F., and Lou, J. S. Creatine monohydrate in ALS: effects on strength, fatigue, respiratory status and ALSFRS. They’re always from people asking the same basic questions. Int J Sports Med 2000;21:139-45. View abstract. Urbanski, R. L., Vincent, W. J., and Yaspelkis, B. Neurology 10-14-2003;61(7):925-930. Vanakoski J, Kosunen V, Meririnne E, Seppala T. Creatine and caffeine in anaerobic and aerobic exercise: effects on physical performance and pharmacokinetic considerations. 83rd Annual Experimental Biology Meeting 1999; Mendel, R. W., Blegen, M., Cheatham, C., Antonio, J., and Ziegenfuss, T. Effects of creatine on thermoregulatory responses while exercising in the heat. View abstract. Neurorehabil Neural Repair 2007;21:107-15. Oral creatine supplementation. Sports Med 1999;27(2):97-110. Liver and kidney dysfunction have also been suggested on the basis of small changes in markers of organ function and of occasional case reports, but well controlled studies on the adverse effects of exogenous creatine supplementation are almost nonexistent. View abstract. Creatine supplementation (3 g/day) and bone health in older women: a 2-year, randomized, placebo-controlled trial. But you should be aware Saidi, H. and Mani, M. Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report. The effects of polyethylene glycosylated creatine supplementation on muscular strength and power. Francaux M, Poortmans JR. Eur.J.Appl.Physiol 2004;91(5-6):628-637. Galvan E, Walker Dk, Simbo SY, et al. View abstract. Newman, J. E., Hargreaves, M., Garnham, A., and Snow, R. J. View abstract. View abstract. Appl Physiol Nutr Metab. Creatine supplementation and health variables: a retrospective study. Vandeberghe K, Gillis N, Van Leemputte M, et al. Throughout the years, there have been minimal negative side effects. View abstract. Arch Neurol. Early research shows that taking creatine might reduce muscle loss and improve nutrition in people with CKD on dialysis. Am.J.Respir.Crit Care Med. Candow, D. G., Little, J. P., Chilibeck, P. D., Abeysekara, S., Zello, G. A., Kazachkov, M., Cornish, S. M., and Yu, P. H. Low-dose creatine combined with protein during resistance training in older men. Lee, C. L., Lin, J. C., and Cheng, C. F. Effect of caffeine ingestion after creatine supplementation on intermittent high-intensity sprint performance. Rawson ES, Wehnert ML, Clarkson PM. 2009;(3):CD006455. Nelson, A. G., Day, R., Glickman-Weiss, E. L., Hegsted, M., Kokkonen, J., and Sampson, B. Creatine supplementation alters the response to a graded cycle ergometer test. Lugaresi, R., Leme, M., de, Salles Painelli, V, Murai, I. H., Roschel, H., Sapienza, M. T., Lancha Junior, A. H., and Gualano, B. Willoughby, D. S. and Rosene, J. View abstract. 2020;52(1):120-130. 2011;34(4):211-217. (check all that apply), What factors are most important to you? Food Sci Nutr. Isbrandt, D. and von Figura, K. Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA. 2016 Sep;54(3):487-95. Chetlin, R. D., Gutmann, L., Tarnopolsky, M. A., Ullrich, I. H., and Yeater, R. A. Effects of ingesting creatine containing supplements during training on blood lipid profiles. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. View abstract. Kreider RB, Kalman DS, Antonio J, Ziegenfuss TN, Wildman R, Collins R, Candow DG, Kleiner SM, Almada AL, Lopez HL. 2008;(1):CD006052. Prevention of traumatic headache, dizziness and fatigue with creatine administration. Exp Neurol 1999;157:142-9. Int J Sport Nutr. 2007;21(3):655-660. Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis. Amino Acids 2012;42(6):2299-305. View abstract. J Pediatr. View abstract. An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease). Your body may take some time to get used to creatine supplements. Ann Thorac Surg 1996;61:67-75. View abstract. Arch Phys Med Rehabil. Kerksick, C. M., Wilborn, C. D., Campbell, W. I., Harvey, T. M., Marcello, B. M., Roberts, M. D., Parker, A. G., Byars, A. G., Greenwood, L. D., Almada, A. L., Kreider, R. B., and Greenwood, M. The effects of creatine monohydrate supplementation with and without D-pinitol on resistance training adaptations. Eur.J Appl.Physiol 2001;84(4):321-328. View abstract. Circulation 2000;102:191-6. View abstract. Exogenous creatine supplements are often consumed by athletes in amounts of up to 20 g/day for a few days, followed by 1 to 10 g/day for weeks, months and even years. Am J Med 2014;127(8):e7-8. Multiple sclerosis (MS). Effects of oral creatine loading on single and repeated maximal short sprints.  |  You're "hot" from pumping iron? J Sports Med Phys Fitness. Scand J Med Sci Sports 1993;3:143-149. Creatine supplementation during pre-season football training does not affect fluid or electrolyte status. This can help improve movement and reduce seizures. Eur.J.Appl.Physiol 2011;111(5):749-756. Mujika I, Padilla S, Ibanez J, et al. Gordon, P. H., Cheung, Y. K., Levin, B., Andrews, H., Doorish, C., Macarthur, R. B., Montes, J., Bednarz, K., Florence, J., Rowin, J., Boylan, K., Mozaffar, T., Tandan, R., Mitsumoto, H., Kelvin, E. A., Chapin, J., Bedlack, R., Rivner, M., McCluskey, L. F., Pestronk, A., Graves, M., Sorenson, E. J., Barohn, R. J., Belsh, J. M., Lou, J. S., Levine, T., Saperstein, D., Miller, R. G., and Scelsa, S. N. A novel, efficient, randomized selection trial comparing combinations of drug therapy for ALS. View abstract. J Ren Nutr. J.Appl.Physiol 2002;92(2):513-518. J.Diet.Suppl 2010;7(3):240-252. View abstract. A., Hatfield, D. L., Fragala, M. S., and Volek, J. S. Creatine supplementation improves muscular performance in older women. Curr Ther Res 1989;46:67-73. Single- and multiple-dose pharmacokinetics of oral creatine. Syrotuik, D. G., Game, A. No, studies have shown that consumption of creatine monohydrate does not cause any serious adverse side effects. J Virol 1995;69:4656-7. Clin Cardiol. View abstract. View abstract. You should not take more Amplified Creatine 189 than directed on the label to avoid gastrointestinal side effects 3 4 5. Simon, D. K., Swearingen, C. J., Hauser, R. A., Trugman, J. M., Aminoff, M. J., Singer, C., Truong, D., and Tilley, B. C. Caffeine and progression of Parkinson disease. View abstract. The effect of creatine supplementation on blood pressure, plasma creatine kinase, and body composition. View abstract. Magn Reson.Imaging 2010;28(5):698-707. Semenovsky, M. L., Shumakov, V. I., Sharov, V. G., Mogilevsky, G. M., Asmolovsky, A. V., Makhotina, L. A., and Saks, V. A. J.Athl.Train. Poortmans JR, Francaux M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Chwalbinska-Moneta, J. Golini J, Jones WL. Studies on the safety of creatine supplementation. Creatine doesn't seem to improve serving ability in tennis players. Ann Rheum Dis 1985;44:199-201. 2009;108(3):711-713. Evaluation of creatine analogues as a new class of anticancer agents using freshly explanted human tumor cells. Learn about potential creatine side effects. View abstract. J Strength.Cond.Res 2007;21(3):668-677. 1995;5(2):94-101. Br J Cancer 2015;112(7):1247-50. Eur J Cardiothorac.Surg 1991;5(2):74-81. 2020;12(6):E1780. View abstract. View abstract. 2002;3(1):43-46. Ara, G., Gravelin, L. M., Kaddurah-Daouk, R., and Teicher, B. Smith, A. E., Fukuda, D. H., Ryan, E. D., Kendall, K. L., Cramer, J. T., and Stout, J. Ergolytic/ergogenic effects of creatine on aerobic power. 2004;51(4):875-882. Am.J.Sports Med. Nausea, diarrhea, etc. Burke, D. G., Silver, S., Holt, L. E., Smith, Palmer T., Culligan, C. J., and Chilibeck, P. D. The effect of continuous low dose creatine supplementation on force, power, and total work. M Simonds a Wong B et al report any adverse effects, but body mass failure CHF... Candow DG, Zello GA, ling B, Cutler M, Shao a, Pertille a, Osher,... 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