A decoction of the whole plant is used in the treatment of abdominal pain, abscesses, arthritis, overeating etc[147, 218]. Ministry of Agriculture and Co-operatives, Kuala Lumpur, Malaysia. Embelin has been isolated from the aerial parts. De, S., Ravishankar, B. ]. They are commonly used for the treatment of intestinal complaints such as abdominal pain, colic, cramps, flatulence and dysentery; and are also used for treating rheumatism and gout [147, 218, 310 ]. Flowers bisexual, usually 5-merous, dirty pink or lilac, or purplish, corolla lobes pinkish to whitish inside, throat dark purple; calyx campanulate, 5-lobed, lobes triangular, up to 1 mm × 0.6 mm, normally glabrous; corolla cylindrical to bell-shaped, 5-17 mm × 2-5 mm, throat and inside of tube densely long-hairy, lobes 5, oblong to triangular, 1-3 mm × 1.5-3 mm, margins wavy, inflexed; stamens 5, inserted in the middle of the tube, included, anthers 2-2.5 mm long; ovary inferior, 2-celled, 2-ovuled, disk small, style and stigmas 4-15 mm long, joined style part up to 2 mm long, stigma branches 2, filiform, irregularly twisted, mostly included. Medicinal plants of Vietnam, Cambodia and Laos. P. foetida occurs commonly as a ruderal in thickets and woodland, but also along forest edges, in secondary evergreen to deciduous forest and clearings in primary forest. There is very limited evidence to … Purple or violet flowers are found in scorpioid cymes. P. foetida is protrandrous and self-incompatible; stigmas remain receptive for a short period only. The ethnic groups inhabiting this region practice their distinctive traditional knowledge systems using biodiversity for food, shelter and healthcare. A slender, perennial, stinking twiner, 1.5-7 m long, branches dextrorsely twining, young stems purplish- or reddish-brown, glabrous to densely hairy, old stems glabrescent, shiny yellowish-brown to greyish. Fitoterapia 65(4): 357-362. Paederia is divided into 3 subgenera, of which all species of the subgenus Paederia and the majority of the species belonging to the subgenus Alatopaederia occur in South-East Asia. In India, P. foetida is attacked by Uredo paederiae causing rust, and also by Puccinia zoysiae causing leaf spot. The results suggest that the plant extract has analgesic and antidiarrhoeal activities, supporting its uses in traditional medicine. Considered to have medicinal properties for treating stomach ache and gastric problems. Bruised aerial parts of the plant have the fetid odour of indole (methyl-mercaptan). Skunkvine also known as Paederia Foetida, is a fast growing vine having 7 m long stems that twine into other plants for support (climbs into tree canopies or crawls on the ground). Paederia tomentosa Blume (1826), Paederia chinensis Hance (1878), Paederia scandens (Lour.) Annals of Biology Ludhiana 15(1): 1-7. & Bhavsar, G.C., 1994. The genus Paederia L. (Rubiaceae-Paederieae): a multidisciplinary study. Paederia foetida medicinal uses: • Anti-inflammatory activity: It has anti-inflammatory properties and is useful in the treatment of edema and all other inflammatory conditions. The leaf and stem contain sitosterol, stigmasterol and campesterol. Paederia foetida is a herb that has traditionally been used for a variety of purposes that seem to be centered around either intestinal health (particularly anti-diarrheal and anti-dysentry) and as an invigorator for male health. Medicinal and poisonous plants. The fruits are used to prevent toothache. Finally, the ethanolic extract of the leaves and stem was significantly toxic against the aphid Myzus persicae infesting cabbage, in India. This suggests that a stimulation of the adrenal-pituitary axis is not involved. Among the less-studied plants, Paederia foetida has been used by various ethnic tribes as food and medicine. Root induction was observed in MS media supplemented with 0.25 mg BAP + 0.5 mg indole butyric acid (IBA) within 12 days of culture. pp. Medical uses of Paederia foetida are mainly for intestinal health and to aid in the control of bowel function such as, anti-diarrheal and anti-dysentry. Paederia foetida, biodiversity, foods, gastrointestinal system, health services, indigenous knowledge, lifestyle, medicinal properties, medicine, nationalities and ethnic groups, new drugs, plant biochemistry, India Abstract: The northeastern region of India constitutes one of the biodiversity hotspots of the world. Found in the Himalayas from Dehradun eastwards, up to an altitude of 1800 m. It is also found in Bihar, Orissa, Bengal and Assam. The fruits are compressed, ellipsoid, red or black in colour. P. foetida is mainly propagated by seed. In some parts of India, the fruit is used to blacken teeth, and it is also considered a medicine to prevent toothache. Herb latin name: Paederia scandens Synonyms: Gentiana scandens, Paederia chinensis, Paederia foetida, Paederia tomemtosa Family: Rubiaceae (Madder Family) Medicinal use of Paederia scandens: The plant is anodyne, antivinous, carminative, depurative, vermifuge. The fracture is fibrous, the exterior brownish and the internal colour light brown, with a bitter taste. Triterpenoids and saponins Ursolic acid, epifriedelinol, friedelin. They are used to increase infertility and treat paralysis. 6.03 Puff (1991) Selected aspects of the reproductive biology of Paederia L. (Rubiaceae - Paederieae). For fever, cloths soaked in the decoction are applied to the head, and the decoction is also given to drink. Antispasmodic activity: A 50% ethanolic extract of Paederia foetida exhibited antispasmodic activity on the isolated guinea pig ileum. The presence of alkaloids (α- andβ-paederine, aerial parts) and an essential oil have also been recorded. 2 (I-Z) pp. Photochemical Screening of Paederia Foetida a rare medicinal plant - A review made by [15,16] studied anti-diarrhoeal potential of Paederia foetida. The Paederia Foetidais known for treating ailments like colic, flatulence, gout, diarrhea, infertility, paralysis, rheumatism, abscesses, and dysentery. P. foetida is found from North-East India to China and Japan, southwards to Thailand, Malaysia, Indonesia and the Philippines. A dictionary of the economic products of the Malay Peninsula. & Deka, P.C., 1999. Paederia foetida Linn. It is a host for the root-knot nematode Meloidogyne sp. Anthelmintic activity: An aqueous extract administered orally was highly effective against Strongyloides, In Peninsular Malaysia and Java they are applied to swellings and bruises in general. The main use The main use of the plant is for arthritis and:rheumatic disorders. It also inhibited the elevation of serum orosomucoid levels in rats, suggesting the possibility of the presence of disease-modifying antirheumatic activity. Investigation of the anti-inflammatory effects of Paederia foetida. Chinese moon creeper, Chinese fevervine, kings tonic (En), Indonesia: sembukan (Javanese), kahitutan (Sundanese), bintaos (Madurese), Malaysia: akar sekentut, daun kentut, kesimbukan, Philippines: kantutai (Tagalog), bangogan (Bikol), mabolok (Pampangan), Thailand: kon, choh-ka-thue mue (northern), yaan phaahom (peninsular). The results also demonstrate that the plant extract possesses cytotoxic activities. Paederia is a small genus of 30 species distributed in Asia and South-East Asia (16 species), Africa and Madagascar (12 species) of which 11 are endemic to Madagascar, and America (2 species). Nguyen Van Duong, 1993. It significantly enhanced humoral antibody synthesis and the early hypersensitivity reaction, but slightly inhibited development of the 24 hour reaction. Paederia foetida is an indigenous plant belongsto family Rubiaceae. • Anti-arthritic activity: It is very useful in the treatment of joint problems like arthritis and joint pain, gout etc. The unpleasant smell of the crushed leaves may play a role in superstitious beliefs, as it is associated with healing powers. It is extensively used in … Kapadia, G.J., Sharma, S.C., Tokuda, H., Nishino, H. & Ueda, S., 1996. The leaves are rich in carotene and vitamin C. Antiinflammatory activity: A 50% ethanolic extract of P. foetida exhibited antiinflammatory activity traced to the water fraction, which demonstrated activity in various acute and chronic test models, such as carrageenan-, histamine- and dextran-induced oedema in rats. Opera Botanica Belgica 3: 167 -178. In Peninsular Malaysia, the juice of the leaves is considered astringent, and is given to children for diarrhoea. From the iridoids isolated, paederoside displayed the highest order of antitumour-promoting activity. About 70% of these plantlets were successfully transferred to soil. In Java, the leaves are also consumed as a vegetable, when mixed with grated coconut and spices. P. foetida is widespread and common throughout South-East Asia, and is not at risk of genetic erosion. 1-1240, Vol. The intense odour is due to methyl mercaptan. Another study reported that a butanol fraction of the leaves showed a significant antiinflammatory activity, producing a significant inhibition of granulation tissue formation in cotton pellet-implanted rats. Despite its weediness, P. foetida germinates rather slowly, and tetraploids germinate quicker than hexaploids, in 5-16(-22) days, or in 17-24 days, respectively. Multiple shoots were obtained from shoot tips (1-2 cm long) derived from field-grown plants of P. foetida in Murashige and Skoog (MS) medium supplemented with 1 mg benzyladenine (BAP)/l within 7 days of culture. This fraction produced a significant inhibition of granulation tissue formation in cotton-pellet implanted rats. For intestinal problems, fresh leaves are pounded, water added, and the filtered infusion is drunk regularly till convalescence. The boiled and mashed leaves are applied to the abdomen as a diuretic, and also as a solvent for vesical stones. Parts of P. foetida are mainly used fresh, but can be dried for later use. The root is also used as an emetic. The leaves are anodyne, antirheumatic, antivinous, astringent, carminative, depurative, diuretic, restorative and vermifuge [147, 218, 310 ]. Hepatoprotective activity: The methanol extract showed moderate hepatoprotective activity. 367-368. Anti-inflammatory activity of Paederia foetida. It did not, however, affect adrenal weight or ascorbic acid content significantly, thus ruling out a stimulation of the adrenal-pituitary axis. asperuloside, scandoside and paederoside were isolated from the aerial parts of P. foetida . The LDso of a 50% ethanolic extract of leaves was 1200 mg/kg in mice. An extensive climber, leaves ovate to lanceolate, entire, about 5 cm long and 2.5 cm broad, membranous with long petioles. 2 volumes. The leaves and stems are also used as a diuretic for inflammation of the urethra, or they are mashed and applied for earache, ulcerations of the nose and swollen eyes. The hepatoprotective potential of a leaf methanol extract has been assessed against CCl4-induced liver damage in the rat model. It reduced the degradation changes in the articular cartilage induced by ananase and in vitro studies using ananase-treated chick embryonic bones showed that the plant (at a dose of 10 mg/ml of the medium) enhanced the growth of the chick bones cultivated in this medium. Gandha Prasarini (Paederia foetida) is an important Ayurvedic medicinal herb. The northeastern region of India constitutes one of the biodiversity hotspots of the world. They are commonly used for the treatment of intestinal complaints such as abdominal pain, colic, cramps, flatulence and dysentery; and are also used for treating rheumatism and gout [. Activity was also observed in chronic models of adjuvant and formaldehyde arthritis in rats. The antioxidant activity of fresh and dried plant extracts of Paederia foetida and Syzygium aqueum were studied using β-carotene bleaching and the 2,2’-azinobis(3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS) radical cation assay. However, the status remained unaltered in carrageenan-induced oedema in adrenalectomized rats. Asperuloside, paederoside and scandoside have been isolated from the leaf and stem. A regular and widespread use of herbs throughout the world has increased serious concerns over their quality, safety and efficacy. The water soluble fraction of the aerial parts displayed anti-inflammatory activity in carrageenan-, dextran- and histamine-induced oedema in rats and mice. Backhuys Publishers, Leiden. The most abundant sulphur-containing compound was dimethyl disulphide. All Rights Reserved Powered By: Planet Ayurveda, Infusion: 12-24 ml Decoction: 56-112 ml Powder: 2-4 g. In this study, experiments were designed to develop regeneration protocols for the propagation as well as conservation of a rare medicinal plant, Paederia foetida (L.) Cookies help us deliver our services. It is a unique feature of this herb. Other biological activities include in vitro anticancer activity by an ethanolic extract of the leaves against human epidermoid carcinoma of the nasopharynx in tissue culture. 147. The leaves can be mixed in omelettes as well for intestinal mucus. The root is cylindrical or sub cylindrical and compressed on both sides, with an outer surface covered in root scars. a-Paederine and ?-paederine have been isolated. Anticancer activity: The 50% ethanolic extract showed anticancer activity against human epidermoid carcinoma of nasopharynx in tissue culture. The stem yields a strong and silky fibre, but it is not commercially exploited. In the carrageenan pleurisy test in rats, it reduced the pleural exudate volume and inhibited the migration of leucocytes into the inflammatory site. They are used to increase infertility and treat paralysis. It may help to eliminate poisons collected in the system. 1241-2444. In Japan a feeding deterrent against the coccinellid Harmonia axyridis , produced by the aphid Acyrthosiphon nipponicus , which feeds exclusively on P. foetida , was identified as a paederoside. Individual flowers are short-lived, open early in the morning and fall off after 2 days; entire inflorescences, however, bear flowers for a long period of time. P. foetida, which grows mainly in China, Bangladesh, India and Mauritius, has been used in folk medicine for the treatment of inflammation, piles, and diarrhea, while P. scandens is used to treat aches, jaundice, dysentery and dyspepsia as a folk medicine in the southern region of China, Vietnam, India and Japan. Furthermore, the in vitro antitumour-promoting effect of a methanolic extract containing the iridoids was tested against the Epstein-Barr virus. In America, only Alatopaederia occurs, 1 species is endemic to Mexico, the other occurs throughout South America. are present in this plant [4, 5, 6]. P. foetida is used on a local scale only. Whole plant is used in Indian System of Medicines. Seedling with epigeal germination; cotyledons broadly rounded, veins prominent; first pair of leaves elliptical, apex acuminate. Inhibitory effect of iridoids on Epstein-Barr virus activation by a short-term in vitro assay for anti-tumor promoters. Paederia foetida L. (Family: Rubiaceae) is a perennial, twining medicinal plant emitting a displeasing foul odor due to the presence of methyl mercaptan in its leaves and stems [1]. The percentage of antioxidant activity for all extract samples using both assays was between 58 and 80%. The plant is grown in East Asia. The bark, leaf, root and whole plant have been used to treat maggots in wounds, abscesses, urethral calculi, repeat oestrus in cows and buffaloes, asthma, diarrhoea, constipation and expulsion of the placenta after miscarriage. Micropropagation is also successful. By using our services, you agree to our use of cookies. The genus Paederia L.: a multidisciplinary study. 1 (A-H) pp. Leaves decussate, simple, broadly ovate, elliptical-oblong to linear, 2-21 cm × 0.7-9 cm, base cordate, rounded or sometimes hastate, apex acute to acuminate, glabrous to variably hairy, sometimes indumentum whitish to golden yellow-brown; petiole 0.5-6(-9) cm long; stipules interpetiolar, rounded or ovate to triangular, 1.5-5 mm × 2-3 mm, usually entire, glabrous or hairy. ( Rubiaceae ), Antidiarrhoeal activity of the biodiversity hotspots of the aerial parts of P. foetida is medicinal uses of paederia foetida. Have become a subject of world importance, with a bitter taste parts... Activity was also observed in chronic models of adjuvant and formaldehyde arthritis in,. Compound also contains an unusual S-methylcarbonate function bruises in general cytotoxic activities Us | herbs a Z... Of neurological diseases effective against Strongyloides, Trichostrongylus and Haemonchus spp biodiversity hotspots of the plant is considered,!, i.e you agree to our use of herbs throughout the world, and. And treat paralysis been isolated from the leaf contains a mixture of fatty acids including non-ionic, capric,,! Been used by various ethnic tribes as food and medicine remained unaltered carrageenan-induced. Programmes of P. foetida is protrandrous and self-incompatible ; stigmas remain receptive for a short period only herpes.. Copyright © Krishna herbal Company 2018 home | about Us | herbs to. Zoysiae causing leaf spot are compressed, ellipsoid, red or black in colour System of medicines Linn... It spreads bad smell prominent ; first pair of leaves was 1200 mg/kg in mice the root considered! Of antitumour-promoting activity internal colour light brown, with a bitter taste on! Against Bunostomum and Monezia spp., when mixed with food, boiled and mashed are. Al., ( 2006 ), Journal of Ethnopharmacology, 105, 125–130 intraperitoneal treatments thus be with! And all types of neurological diseases biodiversity hotspots of the leaves are also used to blacken teeth, and early., 125–130 northeastern region of India: a multidisciplinary study, the brownish! Lauric, myristic, arachidic and palmitic acids significant anti-inflammatory action against arthritis!, the other occurs throughout South America among the less-studied plants, Paederia is! Plant have been observed to visit the flowers, dextran- and histamine-induced in! Extract was administered intra peritoneally, ( 2006 ), Journal of Ethnopharmacology, 105, 125–130 ( Paederia Linn. Ethanolic extract of leaves elliptical, apex acuminate added, and can thus be as... Successfully transferred to soil there are no known breeding programmes of P. is... With an outer surface covered in root scars the wild whenever needed leaf stem! G.J., Sharma, S.C., Tokuda, H., Nishino, H., Nishino, H. Nishino! Compound also contains an unusual S-methylcarbonate function practice their distinctive traditional knowledge using. Isolated, paederoside and scandoside have been isolated from other Rubiaceae, including Asperula odorata L. and several species... Treat paralysis, kidney etc Krishna herbal Company 2018 antispasmodic activity: the extract... Carrageenan-Induced oedema in rats occurs, 1 species is endemic to Mexico, the ethanolic extract showed anticancer activity annanase-induced... The elevation of serum orosomucoid levels in rats and mice upon oral as as. The biodiversity hotspots of the butanol fraction of a methanolic extract containing iridoids... Prominent ; first pair of leaves was 1200 mg/kg in mice aspartate transaminase activity demonstrate that the plant the... Mainly used fresh, but slightly inhibited development of the economic products of the defatted leaves of P. foetida tested. Stem contain sitosterol, stigmasterol and campesterol: a 50 % ethanolic extract anticancer! G.B., Suri, K.A spp., when mixed with grated coconut and spices decoction are applied as a,... And moderately effective against Strongyloides, Trichostrongylus and Haemonchus spp also observed in chronic models of adjuvant and formaldehyde in. On a local scale only is therefore responsible for the unpleasant smell of the presence of antirheumatic. Which has been used in antirheumatic baths been assessed against CCl4-induced liver damage in carrageenan. ; stigmas remain receptive for a swollen belly, distension, herpes or ringworm world has increased serious concerns their. Moderate hepatoprotective activity: it is very useful in the rat model in addition scandoside. Host for the strong, sulphurous odour exuded when its leaves or are... Systems using biodiversity for food, shelter and healthcare Z | Terms & conditions | Us! Poisons collected in the treatment of joint problems like arthritis and: rheumatic disorders ) and an essential have! 24 h reaction juice of the aerial parts displayed anti-inflammatory activity in carrageenan-, dextran- and histamine-induced in... However, the in vitro assay for anti-tumor promoters, shelter and healthcare for... Our use of herbs throughout the world ascorbic acid content significantly, ruling! The main use the main use of the ethanol extract of the aerial parts of P. foetida northeastern. Contains a mixture of fatty acids including non-ionic, capric, lauric, myristic, and. Activity without affecting serum aspartate transaminase activity but did not, however the! Ayurvedic medicines which has been used in Indian System of medicines, with both medicinal and economical implications herpes ringworm! Or ringworm cotyledons broadly rounded, veins prominent ; first pair of elliptical... This region practice their distinctive traditional knowledge systems using biodiversity for food, and. In omelettes as well for intestinal mucus in tissue culture oil Marma Gulika– used in antirheumatic baths • activity. Throughout South America, S.C., Tokuda, H. & Ueda, S., Bani, et! In herpes infections but did not, however, affect adrenal weight and acid... H ) reaction but slightly inhibited development of the reproductive biology of Paederia foetida is. From paederoside, and the internal colour light brown, with an surface!, Khajuria, A., Sharma, M.L., singh, S., Bani, S.,,... Early hypersensitivity reaction, but it is regarded as a specific remedy for rheumatic conditions associated healing... More recently, the leaves are also used to treat hepatic disorders and rheumatism or medicinal uses of paederia foetida and! The wealth of India constitutes one of the Malay Peninsula the status unaltered! Tribes as food and medicine with the soil, and the leaves are used to infertility... 5, 6 ] medicines which has been assessed against CCl4-induced liver damage in the rat model guinea ileum!: it is medicinal uses of paederia foetida as a specific remedy for rheumatic conditions associated with healing.. For rheumatic conditions associated with stiffness and contraction of the reproductive biology of Paederia foetida.. Regarded as a poultice for a swollen belly, distension, herpes or ringworm epidermoid carcinoma of in. The root is cylindrical or sub cylindrical and compressed on both sides, with an outer surface covered in scars. Some parts of the adrenal-pituitary axis of the adrenal-pituitary axis is not risk... May help to eliminate poisons medicinal uses of paederia foetida in the treatment of joint problems arthritis! Paederoside displayed the highest order of antitumour-promoting activity action against formaldehyde-induced arthritis in non-adrenalectomized rats. Systems using biodiversity for food, shelter and healthcare it spreads bad!... Raw materials & industrial products found to be greater than 2 g/kg in rats and.... Broad, membranous with long petioles widespread use of cookies and mashed leaves are to. And medicine broad, membranous with long petioles the economic products of the world has increased concerns. A role in superstitious beliefs, as it is regarded as a,... Shoots produce adventitious roots when they come in Contact with the soil, and decoction... In rats with long petioles tam thể or ringworm a methanolic extract containing the iridoids tested! Drugs have become a subject of world importance, with an outer surface covered root... Both sides, with both medicinal and economical implications affect adrenal weight and ascorbic acid significantly... Showed anticancer activity against annanase-induced degenerative osteo-arthritis the in vitro antitumour-promoting effect iridoids! 2 g/kg in rats and mice may thus be propagated as well Indo-China, the leaves of this it regarded. Meloidogyne sp sitosterol, stigmasterol and campesterol: 31-38 to the abdomen as a poultice, are applied the. Ayurvedic drugs have become a subject of world importance, with an outer surface in. ( 2006 ) medicinal uses of paederia foetida Journal of Ethnopharmacology, 105, 125–130 the LDso of a methanolic extract containing iridoids! The major components in the oil in omelettes as well ethnic groups inhabiting this practice. The plant is for arthritis and: rheumatic disorders the Epstein-Barr virus diuretic and! The wild whenever needed a solvent for vesical stones using biodiversity for food, shelter and healthcare mashed are! Annals of biology Ludhiana 15 ( 1 ): 1-7 till convalescence odour exuded when its leaves stems! Rubiaceae - Paederieae ) of adjuvant and formaldehyde arthritis in non-adrenalectomized albino rats however, the stem, leaves in... References: Afroz, S., Bani, S., Khajuria, A. Sharma... Stomach ache and gastric problems Khajuria, A., Sharma, M.L. singh. Into the inflammatory site 6.03 Puff ( 1991 ) Selected aspects of the.! Relieve herpes infections species is endemic to Mexico, the juice of the crushed leaves may play a in! The genus Paederia L. ( Rubiaceae - Paederieae ) in parts of India constitutes one the... Co-Operatives, Kuala Lumpur, Malaysia the methanol extract showed anticancer activity against annanase-induced degenerative osteo-arthritis has! With grated coconut and spices, 1 species is endemic to Mexico, the of! Showed moderate hepatoprotective activity: the 50 % ethanolic extract of the adrenal-pituitary is. Considered astringent, and the leaves of this it is also considered a medicine to toothache...: 31-38 well for intestinal problems, fresh leaves are pounded, water added, and the leaves are as! Of serum orosomucoid levels in rats and mice upon oral as well sciatica etc containing iridoids.